Aggregates feel the strain

Editorial M ast cells feel the strain *

See article by Huang et al. [1] (pages 150 –160) in this cytokines, prostanoids, platelet activators, vasoactive issue. agents and growth factors [8]. Mast cell activation may also have a role to play in the Mast cells are implicated to be involved in the pathoinitiation and progression of heart disease. Histamine has genesis of atherosclerosis and acute coronary syndromes. been shown to promot...

Strain-dependent profile of misfolded prion protein aggregates

Prions are composed of the misfolded prion protein (PrP(Sc)) organized in a variety of aggregates. An important question in the prion field has been to determine the identity of functional PrP(Sc) aggregates. In this study, we used equilibrium sedimentation in sucrose density gradients to separate PrP(Sc) aggregates from three hamster prion strains (Hyper, Drowsy, SSLOW) subjected to minimal ma...

Bimodality, prion aggregates infectivity and prediction of strain phenomenon

We consider a model for the polymerization (fragmentation) process involved in infectious prion self-replication and study both its dynamics and non-zero steady state. We address several issues. Firstly, we give conditions leading to size repartitions of PrPsc aggregates that exhibit bimodal distributions, as indicated by recent experimental studies of prion aggregates distribution [19]. This i...

High shear strain of olivine aggregates: rheological and seismic consequences.

High-pressure and high-temperature torsion experiments on olivine aggregates in dislocation creep show about 15 to 20% strain weakening before steady-state behavior, characterized by subgrain-rotation recrystallization and a strong lattice preferred orientation. Such weakening may provide a way to focus flow in the upper mantle without a change in deformation mechanism. Flow laws derived from l...

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